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cwd transmits to macaque oral intake muscle


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Old 07-04-2017, 07:49 PM   #11
flounder
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Exclamation Prion 2017 conference abstracts on chronic wasting disease cwd tse prion

TUESDAY, JULY 04, 2017

PRION 2017 CONFERENCE ABSTRACTS ON CHRONIC WASTING DISEASE CWD TSE PRION

http://chronic-wasting-disease.blogspot.com/2017/07/prion-2017-conference-abstracts-on.html


kind regards, terry


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Old 07-05-2017, 06:29 AM   #12
hazelvillebucks
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FOUNDER ALL OF THAT FINE WORK FROM PROFESSIONALS , and no work to explore the genesis of cwd , just like mad cow s genesis was not examined after they had something to report to the public.
To up the anti of fear while not exploring what it is that makes the first prion is taking us down a slippery slope that will not end well.When it is found how to create a prion where none existed we will have the answers that we need to combat it. Again it is a fine line between bat science and science.If these bastions of higher learning are correct the word will someday consist mainly of just shed protein cells. That does not pass the sniff test.


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Old 07-12-2017, 01:39 AM   #13
flounder
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Originally Posted by hazelvillebucks View Post
FOUNDER ALL OF THAT FINE WORK FROM PROFESSIONALS , and no work to explore the genesis of cwd , just like mad cow s genesis was not examined after they had something to report to the public.
To up the anti of fear while not exploring what it is that makes the first prion is taking us down a slippery slope that will not end well.When it is found how to create a prion where none existed we will have the answers that we need to combat it. Again it is a fine line between bat science and science.If these bastions of higher learning are correct the word will someday consist mainly of just shed protein cells. That does not pass the sniff test.
http://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2017.4667/epdf

http://www.tandfonline.com/doi/full/10.1080/19336896.2015.1115179

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964855/pdf/kprn-09-06-1115179.pdf

http://www.sciencedirect.com/science/article/pii/S1567134809001956?via%3Dihub

http://forest.wisc.edu/files/pdfs/samuel/2009%20blanchong%20et%20al%20genetic%20susceptibil ity%20chronic%20wasting.pdf

http://lib.dr.iastate.edu/cgi/viewcontent.cgi?article=1083&context=nrem_pubs

***at present, no cervid PrP allele conferring absolute resistance to prion infection has been identified.

P-145 Estimating chronic wasting disease resistance in cervids using real time quaking- induced conversion

Nicholas J Haley1, Rachel Rielinqer2, Kristen A Davenport3, W. David Walter4, Katherine I O'Rourke5, Gordon Mitchell6, Juergen A Richt2 1 Department of Microbiology and Immunology, Midwestern University, United States; 2Department of Diagnostic Medicine and Pathobiology, Kansas State University; 3Prion Research Center; Colorado State University; 4U.S. Geological Survey, Pennsylvania Cooperative Fish and Wildlife Research Unit; 5Agricultural Research Service, United States Department of Agriculture; 6Canadian Food Inspection Agency, National and OlE Reference Laboratory for Scrapie and CWD

In mammalian species, the susceptibility to prion diseases is affected, in part, by the sequence of the host's prion protein (PrP). In sheep, a gradation from scrapie susceptible to resistant has been established both in vivo and in vitro based on the amino acids present at PrP positions 136, 154, and 171, which has led to global breeding programs to reduce the prevalence of scrapie in domestic sheep. In cervids, resistance is commonly characterized as a delayed progression of chronic wasting disease (CWD); at present, no cervid PrP allele conferring absolute resistance to prion infection has been identified. To model the susceptibility of various naturally-occurring and hypothetical cervid PrP alleles in vitro, we compared the amplification rates and efficiency of various CWD isolates in recombinant PrPC using real time quaking-induced conversion. We hypothesized that amplification metrics of these isolates in cervid PrP substrates would correlate to in vivo susceptibility - allowing susceptibility prediction for alleles found at 10 frequency in nature, and that there would be an additive effect of multiple resistant codons in hypothetical alleles. Our studies demonstrate that in vitro amplification metrics predict in vivo susceptibility, and that alleles with multiple codons, each influencing resistance independently, do not necessarily contribute additively to resistance. Importantly, we found that the white-tailed deer 226K substrate exhibited the slowest amplification rate among those evaluated, suggesting that further investigation of this allele and its resistance in vivo are warranted to determine if absolute resistance to CWD is possible.

***at present, no cervid PrP allele conferring absolute resistance to prion infection has been identified.

PRION 2016 CONFERENCE TOKYO

http://prion2016.org/dl/newsletter_03.pdf

TUESDAY, JULY 04, 2017

PRION 2017 CONFERENCE ABSTRACTS ON CHRONIC WASTING DISEASE CWD TSE PRION

http://chronic-wasting-disease.blogspot.com/2017/07/prion-2017-conference-abstracts-on.html



kind regards, terry



Last edited by flounder; 07-12-2017 at 01:41 AM. Reason: added link...tss
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